• Replacement of hormones secreted by target glands
• Treatment of ACTH, TSH, LH, and FSH deficiencies similar to the treatment of primary hormone deficiencies of their respective target organ:
  • ACTH deficiency results in cortisol deficiency: Treatment consists of administration of glucocorticoid hormones (hydrocortisone, dexamethasone, or prednisone) to mimic normal pattern of cortisol secretion; mineralocorticoid replacement rarely necessary.
  • TSH deficiency: Goal of treatment is normal T4 value. Treat with -thyroxine.
  • LH and FSH deficiency: Treatment depends on gender and whether fertility is desired:
    • Men: Testosterone replacement if fertility not desired, gonadotropins for fertility.
    • Women: Estrogen–progesterone (and possibly testosterone) replacement, or for fertility, pulsatile gonadotropins.
  • Recombinant human growth hormone (for treating short stature in children and for treating selected adult patients)
  • Hypoprolactinemia has no treatment.
  • Dosages and administration schedule vary according to age and sex
• Infectious disease: Antibiotics as appropriate
• Inflammatory or granulomatous disease: Specific treatment

Additional Treatment

General Measures

• Outpatient
• Inpatient for surgery when hypopituitarism is a result of pituitary tumor
• Hormonal replacement

Surgery/Other Procedures

For pituitary tumor